Induction of high tolerance to artemisinin by sub-lethal administration: A new in vitro model of P. falciparum.
Artemisinin resistance is a major threat to malaria control efforts.Resistance is characterized by an increase in the Plasmodium falciparum parasite clearance half-life following treatment with artemisinin-based combination therapies (ACTs) and an increase in the percentage of surviving parasites.The remarkably short blood half-life of artemisinin